crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 490253

Časopis

Autori: Baričević, Marinka; Ratkaj, Ivana; Mladinić, Marin; Želježić, Davor; Kraljević Pavelić, Sandra; Lončar, Božana; Mravak Stipetić, Marinka
Naslov: In vivo assessment of DNA damage induced in oral mucosa cells by fixed and removable metal prosthodontic appliances
Izvornik: Clinical oral investigations (1432-6981) 16 (2012), 1; 325-331
Vrsta rada: članak
Ključne riječi: prosthodontic appliances; dental casting alloys; oral mucosa; buccal cells; comet assay; DNA damage
Sažetak:
Abstract: Given long-term effect on oral tissues due to contact with dental appliances, the biocompatibility studies of casting alloys are of great importance. It has been previously documented that metal dental appliances, due to corrosion, might induce genotoxic and mutagenic effects in cells. Therefore, the aim of presented study was to examine the genotoxicity of two dental casting alloys (Co-Cr-Mo and Ni-Cr) commonly used in fixed and removable prosthodontic appliances that are in contact with the oral epithelium for 5 years or more. For that purpose 55 age-matched subjects were included in the study ; 30 wearers of prosthodontic appliances and 25 controls. Buccal cells of oral mucosa were collected and processed for further analysis. The cell viability has been assessed by trypan blue exclusion test, while genotoxic effect of metal ions on DNA in oral mucosa cells was studied by use of alkaline comet assay. Results have shown significantly higher comet assay parameters (tail length and percentage DNA in the tail) in the group wearing metal appliances. Both subjects with Co-Cr-Mo alloy and Ni-Cr alloy showed significantly higher comet assay parameters when compared to controls. It has been confirmed that metal ions released by the two base metal dental casting alloys examined in this study, might be responsible for DNA damage of oral mucosa cells. Therefore, the results of this study emphasize the importance of the in vivo evaluation of dental materials with respect to their genotoxicity, which is of major importance to ensure long-term biocompatibility.
Projekt / tema: 335-0000000-3532, 065-0982464-2532
Izvorni jezik: ENG
Current Contents: DA
Citation Index: DA
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti,Stomatologija
Tiskani medij: da
URL Internet adrese: http://www.springerlink.com/content/b87n63p87404845u/
Broj citata:
Altmetric:
DOI: 10.1007/s00784-010-0489-4
Google Scholar: In vivo assessment of DNA damage induced in oral mucosa cells by fixed and removable metal prosthodontic appliances
Upisao u CROSBI: mravak@sfzg.hr (mravak@sfzg.hr), 8. Stu. 2010. u 14:06 sati



  Verzija za printanje   za tiskati


upomoc
foot_4