Hrvatska znanstvena bibliografija (CROSBI)



Pregled bibliografske jedinice broj: 529221

Časopis

Autori: Vukelić, Lucian; Šoša, Ivan; Cvijanović, Olga; Mađarević, Tomislav; Jotanović, Zdravko; Vukelić Šarunić, Alenka; Štifter, Sanja; Zoričić Cvek, Sanja; Đudarić, Luka; Šestan, Branko; Bobinac, Dragica
Naslov: Correlation of Endothelin-1 mRNA Expression and Bone Structure in Advanced Osteoarthritis
Izvornik: Medical hypotheses (0306-9877) 77 (2011), 5; 927-929
Vrsta rada: članak
Ključne riječi: bone; articular cartilage; endothelin-1; osteoarthritis
Sažetak:
Recent understandings of the vascular contribution of pathophysiology of osteoarthritis (OA) mount new evidence of cross-talking between subchondral bone tissue and articular cartilage that might have a decisive role in a pathophysiology of Osteoarthritis (OA). These understandings include blood flow (or interstitial fluid) impairment in subchondral bone. With regard to the mentioned role of the vasculature, the absence of custom nourishing to articular cartilage, and established, vasoconstrictive role of endothelin-1 (ET-1) it was reasonable to assume that ET-1 has an inconvertible role in pathophysiology of OA. Another moment in pathophysiology of OA is apoptosis of subchondral osteocytes, what induces osteoclastic resorption and at least temporarily reduces the bony support for the overlying cartilage. Since regional dependence of this protein's expression was presumed, we suggest a regional division of subchondral bone by histomorphometrical analysis and quantification of identified protein by Real Time Polymerase Chain Reaction Analysis (RT-PCR). Obtained results should be compared to serum levels of soluble ET-1, what would enforce this methods validity. Herewith, a new screening marker of patients with osteoarthritis would be established. This would enable detection and follow-up of groups threatened by this, growing, cause of disability and decreased quality of life.
Projekt / tema: 062-0620226-0207, 062-0000000-3559, 062-0000000-0073
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: http://dx.doi.org/10.1016/j.mehy.2011.08.015
http://www.sciencedirect.com/science/article/pii/S0306987711004075
http://ac.els-cdn.com/S0306987711004075/1-s2.0-S0306987711004075-main.pdf?_tid=77d5b21ee2812b87bc340f13e91bf7b8&acdnat=1337856148_cb7e2b1e4be89d823140313724b15265
Broj citata:
Altmetric:
DOI: 10.1016/j.mehy.2011.08.015
URL cjelovitog teksta: http://dx.doi.org/10.1016/j.mehy.2011.08.015
Google Scholar: Correlation of Endothelin-1 mRNA Expression and Bone Structure in Advanced Osteoarthritis
Upisao u CROSBI: djluka@medri.hr (djluka@medri.hr), 7. Lis. 2011. u 10:29 sati