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Pregled bibliografske jedinice broj: 534002

Časopis

Autori: Massari, Dražen; Prpić-Massari, Larisa; Kehler, Tatjana; Kaštelan, Marija; Ćurkovic, Božidar; Peršić, Viktor; Ružic, Alen; Laškarin, Gordana
Naslov: Analysis of granulysin-mediated cytotoxicity in peripheral blood of patients with psoriatic arthritis
Izvornik: Rheumatology international (0172-8172) 32 (2012), 9; 2777-2784
Vrsta rada: članak
Ključne riječi: granulysin; cytotoxicity; peripheral blood; psoriatic arthritis
Sažetak:
he objective of the present study was to investigate possible changes in granulysin (GNLY)-mediated cytotoxicity of peripheral blood lymphocytes in psoriatic arthritis (PsA) patients with respect to different phases of the disease. We prospectively enrolled 25 PsA patients in the active phase, 26 PsA patients in remission and 24 healthy controls. The simultaneous detection of intracellular GNLY and cell surface antigens (CD3 and CD56) was performed with flow cytometry. GNLY apoptotic protein was visualised by immunocytochemistry. Natural killer (NK) cell cytotoxicity was analysed with a cytotoxicity assay against human erythroleukaemia K-562 cells. The percentage of GNLY(+) cells did not differ significantly between PsA patients in the acute phase and those in remission ; however, it was always higher than in healthy examinees due to the increased percentage of GNLY(+) cells within T cells, NKT cells, and both, and in the CD56(+dim) and CD56(+bright) NK subsets. The mean fluorescence intensity for GNLY was higher in all lymphocyte subpopulations in the acute phase than in remission and in healthy controls. Accordingly, GNLY-mediated NK cell cytotoxicity against K-562 cells of active phase PsA patients was significantly higher than that in patients in remission or in healthy controls. These findings demonstrated the involvement of GNLY in the worsening of PsA and suggested that GNLY mediated the development of joint lesions.
Projekt / tema: 062-0620239-0197, 062-0620402-0377
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: http://www.ncbi.nlm.nih.gov/pubmed/21830153
http://www.springerlink.com/content/p1410702w1314q75/
Broj citata:
Altmetric:
DOI: 10.1007/s00296-011-2013-9
URL cjelovitog teksta:
Google Scholar: Analysis of granulysin-mediated cytotoxicity in peripheral blood of patients with psoriatic arthritis
Upisao u CROSBI: mkurilic@medri.hr (mkurilic@medri.hr), 4. Stu. 2011. u 15:00 sati



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