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Pregled bibliografske jedinice broj: 539672

Časopis

Autori: Laškarin, Gordana; Peršić, Viktor; Ružić, Alen; Miletić, Bojan; Rakić, Marijana; Travica Samsa, Dijana; Raljević, Damir; Pehar Pejčinović, Vesna; Miškulin, Rajko; Rukavina, Daniel
Naslov: Perforin-mediated cytotoxicity in non-ST elevation myocardial infarction
( Perforin-mediated cytotoxicity in non-ST elevation myocardial infarction )
Izvornik: Scandinavian journal of immunology (0300-9475) 74 (2011), 2; 195-204
Vrsta rada: članak
Ključne riječi: cytotoxicity; lymphocyte; myocardial infarction; NSTEMI; perforin
( cytotoxicity; lymphocyte; myocardial infarction; NSTEMI; perforin )
Sažetak:
The aim of this investigation was to examine the role of perforin (P)-mediated cytotoxicity in the dynamics of tissue damage in patients with non-ST-segment elevation myocardial infarction (NSTEMI) treated with anti-ischaemic drugs. We enrolled 48 patients with NSTEMI in this study [age, 71.5 years ; 61.5/76 (median, 25th/75th percentiles)]. The percentage of total peripheral blood P(+) lymphocytes was elevated owing to the increased frequency of P(+) cells within natural killer (NK) subsets, T and NKT cells in patients on day 1 after NSTEMI when compared with healthy controls. Positive correlations were found between cardiac troponin I plasma concentrations and the frequency of P(+) cells, P(+) T cells, P(+) NK cells and their CD56(+dim) and CD56(+bright) subsets during the first week after the NSTEMI. The expression of P in NK cells was accompanied by P-mediated cytotoxicity against K-562 targets at all days examined, except day 21, when an anti-perforin monoclonal antibody did not completely abolish the killing. The percentage of P(+) T cells, P(+) NKT cells and P(+) NK subsets was the highest on the day 1 after NSTEMI and decreased in the post-infarction period. CD56(+) lymphocytes were found in damaged myocardium, suggesting their tissue recruitment. In conclusion, patients with NSTEMI have a strong and prolonged P-mediated systemic inflammatory reaction, which may sustain autoaggressive reactions towards myocardial tissue during the development of myocardial infarction.
Projekt / tema: 239823, 062-0620402-0377, 041705, 062-0620402-0376
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2011.02554.x/abstract
Broj citata:
Altmetric:
DOI: 10.1111/j.1365-3083.2011.02554.x
URL cjelovitog teksta:
Google Scholar: Perforin-mediated cytotoxicity in non-ST elevation myocardial infarction
Upisao u CROSBI: gordana@medri.hr (gordana@medri.hr), 14. Stu. 2011. u 21:03 sati



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