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Pregled bibliografske jedinice broj: 539779

Časopis

Autori: Peršić, Viktor; Ružić, Alen; Miletić, Bojan; Travica Samsa, Dijana; Rakić, Marijana; Raljević, Damir; Pehar Pejčinović, Vesna; Eminović, Senija; Zaputović, Luka; Laškarin, Gordana
Naslov: Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium After an Acute Coronary Event
Izvornik: Scandinavian journal of immunology (0300-9475) 75 (2011), 2; 231-242
Vrsta rada: članak
Ključne riječi: apoptosis; cytotoxicity; granulysin; interleukin-15; lymphocytes; myocardial infarction
Sažetak:
We aimed to analyze granulysin (GNLY)-mediated cytotoxicity in the peripheral blood of patients with non-ST segment elevation myocardial infarction (NSTEMI) treated with anti-ischaemic drug therapy. Thirty-nine NSTEMI patients with a median age of 70 years, and 28 age-matched healthy subjects were enrolled in this study. On day 7 after MI, the number of GNLY(+) lymphocytes in the peripheral blood increased approximately 6 fold of that in the healthy subjects, measured by flow cytometry. On day 14, the number of GNLY(+) cells significantly decreased in T, NKT, and both CD56(+dim) and CD56(+bright) NK subsets. GNLY(+) CD3(+) and GNLY(+) CD56(+) cells infiltrated central zone of myocardial infarction (MI). In persons who died in the first week after MI, GNLY(+) cells were found within accumulation of apoptotic leukocytes and reached the apoptotic cardiomyocytes in border MI zones probably due to the influence of interleukin-15 in peri-necrotic cardiomyocytes, as it is was shown by immunohistology. By day 28, the percentage of GNLY(+) lymphocytes in peripheral blood returned to the levels similar to that of the healthy subjects. Anti-GNLY mAb decreased apoptosis of K562 targets using peripheral blood NK cells from days 7 and 28 after MI, while in assays using cells from days 1 and 21, both anti-GNLY and anti-perforin mAbs were required to significantly decrease apoptosis. Using NK cells from day 14, K562 apoptosis was nearly absent. In conclusion, it seems that GNLY(+) lymphocytes, probably attracted by IL-15, participates partially in myocardial cell apoptosis, but also hasten resolution of cardiac leukocyte infiltration in NSTEMI patients.
Projekt / tema: 062-0620402-0377, 062-1081875-0545
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: http://www.ncbi.nlm.nih.gov/pubmed/21967803
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.2011.02646.x/abstract
Broj citata:
Altmetric:
DOI: 10.1111/j.1365-3083.2011.02646.x
URL cjelovitog teksta:
Google Scholar: Granulysin Expression in Lymphocytes that Populate the Peripheral Blood and the Myocardium After an Acute Coronary Event
Upisao u CROSBI: gordana@medri.hr (gordana@medri.hr), 14. Stu. 2011. u 22:59 sati



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