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Pregled bibliografske jedinice broj: 547949

Zbornik radova

Autori: Mršić-Pelčić, Jasenka; Pilipović, Kristina; Vujičić, Božidar; Vitezić, Dinko; Župan, Gordana
Naslov: The influence of erythropoietin treatment on oxidative stress parameters in cortex of rats exposed to transient middle cerebral artery occlusion
Izvornik: Periodicum biologorum, 6th Croatian Congress of Pharmacology with International Participation, Vol 112, Suppl 1 / Župan, Gordana (ur.). - Zagreb :
ISSN: 0031-5362
Skup: 6.hrvatski kongres farmakologije sa međunarodnim sudjelovanjem
Mjesto i datum: Opatija, Hrvatska, 15.-18.rujan, 2010.
Ključne riječi: Erythropoietin; oxidative stress; focal cerebral ischemia; rat
Sažetak:
Introduction: Erythropoietin (Epo) plays a central role in process of erythropoiesis. Recently, its neuroprotective potential was reported in various experimental models of brain damage. However, the mechanism of Epo protection is still unclear. In the present study, we examined the effect of Epo administration on lipid peroxidation levels and antioxidant enzymes’ (superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in rat cortex following focal cerebral ischemia. Material and Methods: Focal cerebral ischemia was induced in male HanoverWistar rats (250–350 g) by right middle cerebral artery occlusion (MCAO) model for 1 hr. After 23 hrs of reperfusion, ischemic animals were sacrificed and the levels of lipid peroxidation, SOD and GSH-Px activities were determined spectrophotometrically in the right cortex. Ischemic animals received either vehicle or Epo (5000 IU/kg, intraperitoneally) immediately or 3 hrs after MCAO, and were sacrificed 23 hrs or 21 hrs later, respectively. Sham operated, vehicle treated animals served as the control group. Results: Focal cerebral ischemia significantly increased the level of oxidative lipid damage parameters in the right cortex as compared to the control group without affecting SOD and GSH-Px activities. The decrease in level of lipid peroxidation after Epo treatment was registered but it was not statistically significant. Conclusion: Our results indicate that focal cerebral ischemia caused neuronal damage in the right cortex and that Epo treatment was not effective in preventing above mentioned alteration.
Rad je indeksiran u
bazama podataka:
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Domaća recenzija
Projekt / tema: 062-0620529-0518
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Upisao u CROSBI: jrajic@medri.hr (jrajic@medri.hr), 21. Stu. 2011. u 12:54 sati



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