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Pregled bibliografske jedinice broj: 550405

Časopis

Autori: Ćelić, Tanja; Španjol, Josip; Gršković, Antun; Markić, Dean; Prebilić, Igor; Fučkar, Željko;
Naslov: Bone morphogenetic protein-7 reduces cold ischemic injury in rat kidney
Izvornik: Transplantation proceedings (0041-1345) 43 (2011), 7; 2505-2509
Vrsta rada: članak
Ključne riječi: bone morphogenetic protein; cold ischemia; kidney
Sažetak:
Deceased donor kidneys have a high incidence of delayed graft function attributable to ischemia-reperfusion injury. Although preservation solution and cold storage reduce cold ischemic injury, the depletion of cellular energy and oxidative signalling leads to cellular damage. Because bone morphogenetic protein-7 has renoprotective effect, we have hypothesized that recombinant human bone morphogenetic protein-7 (rh BMP-7) will better preserve kidney tissue exposed to prolonged cold ischemia in comparison with University of Wisconsin (UW) solution. We evaluated how the duration of cold ischemia influences the cold ischemic injury. Levels of lipid peroxidation, protein carbonyl content, as well as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were determined in the kidneys by spectrophotometry after 6, 12, and 24 hours of cold ischemia. Time-dependent increases in the levels of lipid peroxidation and protein carbonyl content at all time points were significantly lower in rhBMP-7- perfused kidneys versus the UW-treated group. SOD activity after 6 hours, as well as GSH-Px activity after 24 hours of cold ischemia was significantly higher in the kidney tissue perfused by rhBMP-7 than in UW group. rhBMP-7 significantly decreases cellular damage in rat kidney versus UW preservation solution and this is attributed to lowering of cold ischemia injury and maintaining prolonged tissue antioxidant activity.
Projekt / tema: 062-0620226-0207
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.transplantation-proceedings.org/article/S0041-1345%2811%2900879-7/abstract
Broj citata:
Altmetric:
DOI: 10.1016/j.transproceed.2011.05.056
URL cjelovitog teksta:
Google Scholar: Bone morphogenetic protein-7 reduces cold ischemic injury in rat kidney
Upisao u CROSBI: dragica@medri.hr (dragica@medri.hr), 22. Stu. 2011. u 13:40 sati



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