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Pregled bibliografske jedinice broj: 589820

Časopis

Autori: Domitrović, Robert; Škoda, Marko; Vasiljev Marchesi, Vanja; Cvijanović, Olga; Pernjak Pugel, Ester; Bival Štefan, Maja
Naslov: Rosmarinic acid ameliorates acute liver damage and fibrogenesis in carbon tetrachloride-intoxicated mice
Izvornik: Food and chemical toxicology (0278-6915) 51 (2013); 370-378
Vrsta rada: članak
Ključne riječi: rosmarinic acid; hepatotoxicity; oxidative/nitrosative stress; inflammation; apoptosis; liver fibrosis
Sažetak:
The aim of this study was to investigate the therapeutic potential of rosmarinic acid (RA), a natural phenolic compound, in the treatment of acute liver toxicity. RA at doses of 10, 25 and 50 mg/kg was administered orally once daily for 2 consecutive days, 6 h after CCl4 intoxication. CCl4 intoxication caused a severe hepatic necrosis and increased serum ALT activity. In the livers, oxidative/nitrosative stress was evidenced by increased 3-nitrotyrosine (3-NT) formation and a significant decrease in Cu/Zn superoxide dismutase (SOD) activity. CCl4 administration triggered inflammatory response in mice livers by activating nuclear factor-kappaB (NF-κB), which coincided with the induction of tumor necrosis factor-alpha (TNF-α) and cyclooxygenase-2 (COX-2). RA improved histological and serum markers of liver damage and significantly ameliorated oxidative/nitrosative stress and inflammatory response in liver tissue. Additionally, RA prevented tumor growth factor-beta1 (TGF-β1) and alpha-smooth muscle actin (α-SMA) expression, suggesting suppression of profibrotic response. Furthermore, RA significantly inhibited the CCl4-induced apoptosis, which was evident from decreased cleavage of caspase-3. The hepatoprotective activity of RA coincided with the amelioration of NF-E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expression. The results of this study indicates that RA possesses antioxidant, anti-inflammatory, antiapoptotic and antifibrotic activity against acute liver toxicity.
Projekt / tema: 006-0061117-1238, 062-0000000-3554, Sveučilište u Rijeci, potpora 13.06.1.2.24
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Farmacija
URL Internet adrese: http://dx.doi.org/10.1016/j.fct.2012.10.021
http://ac.els-cdn.com/S0278691512007661/1-s2.0-S0278691512007661-main.pdf?_tid=9e5456e4-fa93-11e2-9eba-00000aab0f02&acdnat=1375352450_479bb394849f223ad2431784a4e7a7c1
http://www.sciencedirect.com/science/article/pii/S0278691512007661
Broj citata:
Altmetric:
DOI: 10.1016/j.fct.2012.10.021
URL cjelovitog teksta: http://dx.doi.org/10.1016/j.fct.2012.10.021
Google Scholar: Rosmarinic acid ameliorates acute liver damage and fibrogenesis in carbon tetrachloride-intoxicated mice
Upisao u CROSBI: robertd@medri.hr (robertd@medri.hr), 17. Kol. 2012. u 18:21 sati



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