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Pregled bibliografske jedinice broj: 594830

Časopis

Autori: Strenja Linić, Ines; Šoša, Ivan; Kovačević, Miljenko; Ivančić, Aldo; Trobonjača, Zlatko; Grubešić, Aron; Štifter, Sanja
Naslov: Predicting Carotid Restenosis by Comparison of Plaque MCP-1 mRNA Expression and Serum Levels
Izvornik: Medical hypotheses (0306-9877) 80 (2013), 1; 26-28
Vrsta rada: članak
Ključne riječi: MCP-1; atherosclerosis; re-stenosis
Sažetak:
As cardiovascular pathology grows in numbers, research into the discovery of new chemokine biomarkers should not be neglected, as they seem to be paramount in atherosclerosis prevention and its early detection. Chemokines attract and activate leukocytes and are well recognized in the environment of inflammatory response. MCP-1 is a valuable chemokine whose potential to become a new crucial atherosclerosis marker is surely worth investigating. Since quantities of MCP-1 found in lesions are as low as immeasurable, we propose the use of an imunohistochemical method for the quantification of MCP-1 levels in atherosclerotic lesions. Additionally, serum levels of MCP-1 can be measured by commercially available immunoassays. Proposed MCP-1 concentration increase may explain the acceleration in lesion’s atherosclerosis progression as chemokine activation occurs once they bind to specific ligands. If proven, this hypothesis would indicate the need for further studies in order to objectively link the increased MCP-1 expression with carotid re-stenosis.
Projekt / tema: 062-0000000-3544
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: http://dx.doi.org/10.1016/j.mehy.2012.09.022
http://www.sciencedirect.com/science/article/pii/S030698771200446X
http://ac.els-cdn.com/S030698771200446X/1-s2.0-S030698771200446X-main.pdf?_tid=70355c8c-0415-11e3-803b-00000aab0f6c&acdnat=1376397767_97e51d0cb57448ddf4465846550ffe1c
Broj citata:
Altmetric:
DOI: 10.1016/j.mehy.2012.09.022
URL cjelovitog teksta: http://dx.doi.org/10.1016/j.mehy.2012.09.022
Google Scholar: Predicting Carotid Restenosis by Comparison of Plaque MCP-1 mRNA Expression and Serum Levels
Upisao u CROSBI: isosa@medri.hr (isosa@medri.hr), 25. Ruj. 2012. u 16:53 sati



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