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Pregled bibliografske jedinice broj: 604560

Zbornik radova

Autori: Lučin, Ksenija; Matušan-Ilijaš, Koviljka; Damante, Guiseppe; Fabbro, Dora; Đorđević, Gordana; Hadžisejdić, Ita; Grahovac, Maja; Marić, Ivana; Španjol, Josip; Grahovac, Blaženka; Jonjić, Nives
Naslov: Osteopontin expression correlates with nuclear factor-κB activation and apoptosis downregulation in clear cell renal cell carcinoma
( Osteopontin expression correlates with nuclear factor-κB activation and apoptosis downregulation in clear cell renal cell carcinoma )
Izvornik: Abstracts of the 22nd European Congress of Pathology ; u: Virchows Archiv 455 (2009) (S1) 1-148
ISSN: 0945-6317
Skup: European Congress of Pathology (22 ; 2009)
Mjesto i datum: Firenca, Italija, 04.-09.09.2009.
Ključne riječi: apoptosis; carcinoma; renal cell; nuclear factor kappa B; osteopontin
( apoptosis; carcinoma; renal cell; nuclear factor kappa B; osteopontin )
Sažetak:
Osteopontin (OPN) is a phosphoglycoprotein implicated in tumourigenicity and tumour cell metastasis. Apoptosis inhibition is one of mechanisms that contribute to development and progression of cancer and might be initiated by OPN interaction with tumour cell. The aim of this study was to establish the relation between OPN and nuclear factor-kappa B (NF-κB) expression at protein and mRNA level in specimens of clear cell renal cell carcinoma (CCRCC), and their relation to apoptosis. Expression of OPN protein and p50/65 NF-κB subunits was analysed immunohistochemicaly in 94 CCRCC samples and compared mutually and to apoptotic index. Expression of OPN mRNA was analysed using quantitative real-time PCR and compared to OPN and NF-κB protein expression in 22 CCRCC samples. Statistical analysis showed the correlation of OPN expression at protein (p<0.001) and mRNA levels (p=0.019) with NF-κB activation, as well as the inverse association with apoptotic rate (p=0.024). Also, activation of both NF-κB subunits showed inverse correlation with apoptotic index (p=0.003). Our data indicate that activation of NF-kB signalling pathway contributes to OPN-mediated CCRCC progression, partly by mediating prosurvival effect on tumour cells. Therefore, both molecules can constitute potential targets for therapeutic intervention in CCRCC.
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 062-0620095-0078
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: http://link.springer.com/journal/428/455/1/suppl/page/1
Upisao u CROSBI: matusan@medri.hr (matusan@medri.hr), 22. Stu. 2012. u 13:02 sati



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