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Pregled bibliografske jedinice broj: 636469

Časopis

Autori: Domitrović, Robert; Cvijanović, Olga; Pernjak- Pugel, Ester; Škoda, Marko; Mikelić, Lorena; Crnčević-Orlić, Željka
Naslov: Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis
Izvornik: Food and chemical toxicology (0278-6915) 62 (2013); 397-406
Vrsta rada: članak
Ključne riječi: berberine; cisplatin nephrotoxicity; oxidative stress; inflammatory response; autophagy; apoptosis
Sažetak:
The aim of this study was to investigate the therapeutic activity of isoquinoline alkaloid berberine against cisplatin (CP)-induced nephrotoxicity in mice. Berberine was administered at daily doses of 1, 2 and 3 mg/kg by gavage for two succesive days, 48 h after intraperitoneal CP injection (13 mg/kg). Mice were sacrificed 24 h after the last dose of berberine. Histopathological changes and the increase in serum creatinine and blood urea nitrogen (BUN) induced by CP were significantly ameliorated by berberine in a dose-dependent manner. Additionally, oxidative/nitrosative stress, evidenced by the increase in renal 4- hydroxynonenal (4-HNE), 3-nitrotyrosine (3-NT), cytochrome P450 E1 (CYP2E1) and heme oxygenase (HO-1) expression, was significantly reduced. The expression of nuclear factor-kappaB (NF- κB), tumor necrosis factor-α (TNF-α), cyclooxygenase-2 (COX- 2) and inducible nitric oxide synthase (iNOS) was markedly suppressed by berberine, indicating the inhibition of inflammatory response. Treatment of CP- intoxicated animals with berberine also significantly reduced the expression of p53, active caspase-3 as well as autophagy marker light chain 3B (LC3B) in the kidneys. The results of the current study showed the nephroprotective activity of berberine against CP-induced renal injury, which could be attributed to the inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis.
Projekt / tema: 062-0620226-0208, 062-0621261-1269, 062-0000000-3554, Sveučilište u Rijeci, potpora 13.06.1.2.24
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Farmacija
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S0278691513006418
http://ac.els-cdn.com/S0278691513006418/1-s2.0-S0278691513006418-main.pdf?_tid=e82d18d8-f226-11e3-8642-00000aab0f26&acdnat=1402573647_afbd12437a33eccd3820818611ab1f09
Broj citata:
Altmetric:
DOI: 10.1016/j.fct.2013.09.003
URL cjelovitog teksta:
Google Scholar: Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis
Upisao u CROSBI: Robert Domitrović (robert.domitrovic@uniri.hr), 9. Srp. 2013. u 19:13 sati



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