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Pregled bibliografske jedinice broj: 652068

Časopis

Autori: Bobinac, Dragica; Marinović, Marin; Bazdulj, Edo; Cvijanović, Olga; Ćelić, Tanja; Marić, Ivana; Španjol, Josip; Cicvarić, Tedi
Naslov: Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis
Izvornik: Osteoarthritis and cartilage (1063-4584) 21 (2013), 11; 1724-1730
Vrsta rada: članak
Ključne riječi: Cartilage alterations; Osteoarthritis; Osteoporosis; Subchondral cortical bone; Subchondral trabecular bone
Sažetak:
Objective were explore whether osteoporosis (OP) in humans influences the morphological status of the articular cartilage and the subchondral bone. Explore the relationship between the macroscopic aspect of the articular surface and the rate of microscopic changes of both the cartilage and the subchondral bone in OP and osteoarthritis (OA). Femoral heads after total hip replacement were obtained from patients with OP or hip OA (OP, n = 56 ; OA, n = 12). Cartilage degeneration was assessed using the Mankin grading system whereas subchondral bone was evaluated using histomorphometry and Micro-computed Tomography (μCT) scanning system. Thickness of the cartilage layers and subchondral cortical bone (SCB) was measured. Samples with higher total Mankin score have significantly reduced cartilage thickness. Mankin score differed between all OP specimens. In OP samples with lower Mankin scores the thickness of SCB shows a trend of an increase caused by increased levels of bone remodeling. In OP samples with higher Mankin scores we observed thinning of SCB. Structural indices of subchondral trabecular bone (STB) were significantly lower in OP than in OA samples. Thinning of SCB, found in OP samples with higher Mankin scores could be related with the progression of the cartilage degeneration indicating an early-stage OA. Increased levels of bone remodeling and evidently changed morphology of subchondral bone found in OP samples with lower Mankin score indicated that bony bed level must have a role in the progression of the cartilage degeneration.
Projekt / tema: 062-0620226-0209, 062-0620226-0207
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S1063458413008662
http://ac.els-cdn.com/S1063458413008662/1-s2.0-S1063458413008662-main.pdf?_tid=ad915098-81f7-11e4-91af-00000aacb35d&acdnat=1418386329_7f3373e593c8b9e50a666bc82d04656f
Broj citata:
Altmetric:
DOI: 10.1016/j.joca.2013.06.030
URL cjelovitog teksta:
Google Scholar: Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis
Upisao u CROSBI: Ivana Marić (ivana.maric@uniri.hr), 5. Stu. 2013. u 14:54 sati



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