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Pregled bibliografske jedinice broj: 664241

Časopis

Autori: Mikolašević, Ivana; Rački, Sanjin; Bubić, Ivan; Jelić, Ita; Štimac, Davor; Orlić, Lidija
Naslov: Chronic kidney disease and nonalcoholic Fatty liver disease proven by transient elastography
Izvornik: Kidney & blood pressure research (1420-4096) 37 (2013), 4/5; 305-310
Vrsta rada: članak
Ključne riječi: Chronic kidney disease • Non-alcoholic fatty liver disease • Fibroscan
Sažetak:
Preliminary data suggest an association between chronic kidney disease (CKD) and non-alcoholic fatty liver disease (NAFLD). The aim of this study was to further investigate the association between NAFLD and decreased kidney function. A total of 62 patients with CKD were enrolled in the study. Liver stiffness was used to detect liver fibrosis and CAP (controlled attenuation parameter) was used to detect and quantify liver steatosis (Fibroscan®). NAFLD was defined by CAP values ≥238 dB.m(-1). CKD stage III was present in 29 patients (46.8%) and CKD stage IV in 33 patients (53.2%). Out of 62 CKD patients 53 (85.5%) had NAFLD and of these 14/53 patients (26.4%) had also liver stiffness >7 kPa. The severity of liver steatosis was positively correlated with serum creatinine (r=0.399 ; p<0.01) and CRP (r=0.261 ; p<0.05) and negatively correlated with eGFR (r=-0.413 ; p<0.01) and serum iron concentration (r=-0.365 ; p<0.01). The results suggest a high prevalence of NAFLD in CKD patients. The severity of liver steatosis is negatively correlated with kidney function. The study documents the value of ultrasonographic elastography as an effective non-invasive screening method for the diagnosis of NAFLD.
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti,Javno zdravstvo i zdravstvena zaštita
Puni text rada: 664241.Mikolasevic_2013.pdf (tekst priložen 12. Pro. 2013. u 20:56 sati)
Broj citata:
Altmetric:
DOI: 10.1159/000350158
URL cjelovitog teksta:
Google Scholar: Chronic kidney disease and nonalcoholic Fatty liver disease proven by transient elastography
Upisao u CROSBI: Ivan Bubić (ivan.bubic@uniri.hr), 12. Pro. 2013. u 19:33 sati



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