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Pregled bibliografske jedinice broj: 667036

Časopis

Autori: Ivanišević Malčić, Ana; Breen, Lucas; Josić, Djuro; Jukić Krmek, Silvana; Džombeta, Tihana; Matijević, Jurica; Grgurević, Lovro; Pavelić, Krešimir; Krušlin, Božo; Kraljević Pavelić, Sandra
Naslov: Proteomics profiling of keratocystic odontogenic tumours reveals AIDA as novel biomarker candidate
Izvornik: Journal of oral pathology & medicine (0904-2512) 44 (2014), 5; 367-377
Vrsta rada: članak
Ključne riječi: AIDA; biomarkers; immunohistochemistry; keratocystic odontogenic tumor; mass
Sažetak:
Background. Keratocystic odontogenic tumor (KCOT) is a benign, yet aggressive odontogenic tumor. Herein, proteome analysis of KCOT lesions in comparison with control patient-matched tissue unaffected by the disease and with inflammatory odontogenic cysts, namely radicular cysts is presented. Methods. For the proteomics profiling, two complementary proteomics techniques MALDI-MS/MS and LC-ESI-MS/MS were employed. Potential candidate biomarkers were validated by immunohistochemistry. Results. More than 43 proteins were found to be differentially expressed or up-regulated in KCOT lesions in comparison with patient-matched unaffected oral mucosa. These proteins bear important biological functions and are involved in cell proliferation, cytoskeletal re-organization, transcription, cellular motility and apoptosis. In particular, a number of differentially expressed proteins participate in autocrine regulation and signalization within JNK and p38 MAPK signaling pathways. Conclusions. Immunohistochemical validation of chosen putative biomarkers revealed axin interaction partner and dorsalization- antagonist (AIDA), known as a protein that blocks activation of JNK signalling pathway , as a differential biomarker for KCOT lesions on an independent cohort of KCOT tissue samples in comparison with most prevalet intraoseal lesions inflammatory odontogenic cysts.
Projekt / tema: 065-0650445-0434, 335-0000000-3532, 335-0982464-2393, 108-1081870-1884
Izvorni jezik: ENG
Rad je citiran u
bazama podataka:
Web of Science: Science Citation
Current Contents Citation Index
Scopus
Web of Science: Science Citation Index Expanded
MEDLINE
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Dentalna medicina
URL Internet adrese: http://onlinelibrary.wiley.com/doi/10.1111/jop.12239/full
Broj citata:
Altmetric:
DOI: 10.1111/jop.12239
URL cjelovitog teksta:
Google Scholar: Proteomics profiling of keratocystic odontogenic tumours reveals AIDA as novel biomarker candidate
Upisao u CROSBI: Silvana Jukić Krmek (jukic@sfzg.hr), 20. Pro. 2013. u 10:19 sati



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