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Pregled bibliografske jedinice broj: 702706

Zbornik radova

Autori: Mikolašević, Ivana; Rački, Sanjin; Lukenda, Vesna; Orlić, Lidija
Naslov: TRANSIENT ELASTOGRAPHY - A NEW NON-INVASIVE DIAGNOSTIC TOOL FOR ASSESMENT OF FIBROSIS IN RENAL TRANSPLANT RECIPIENTS
Izvornik: Nephrology Dialysis Transplantation (NDT)2014 ; 29(Suppl.3):iii542 / Pieter M. ter Wee (ur.). - OXFORD University Press , 2014. iii542-iii542.
ISSN: 1460-2385
Skup: 51st ERA-EDTA Congress
Mjesto i datum: Amsterdam, Nizozemska, 31.05-03.06.2014.
Ključne riječi: chronic allograft nephropathy; protocol biopsies; transient elastography; renal transplant recipients
Sažetak:
Introduction and aims: Chronic allograft nephropathy (CAN) is the most common cause of kidney allograft failure. Protocol biopsies remain the “gold standard” in CAN recognition. However, renal allograft biopsies have numerous limitations. It’s an invasive procedure connected with risk of complications, patient discomfort, and sampling errors. The aim of our study was to investigate the usefulness of transient elastography (TE) for the assessment of kidney allograft fibrosis in renal transplant recipients (RTRs). Methods: In this cross-sectional study we involved 52 RTRs. Renal allograft stiffness was used to assess its fibrosis by using transient elastography (Fibroscan®, Echosense, Paris, France). In 23 patients with a deterioration of graft function percutaneous renal allograft biopsy was performed closely around the time of TE. Results: We have found that the renal allograft stiffness was highly negatively correlated with estimated glomerular filtration rate (eGFR) (r= -0.640 ; p<0.0001). However, renal allograft stiffness showed a statistically significantly difference between patients who had an eGFR>50 ml/min per 1.73 m2 and patients with eGFR< 50 ml/min per 1.73 m2 (28±2.7vs.33.9±5.5 kPa ; p=0.0003). Also, there was a highly positive correlation between renal allograft stiffness and extent of interstitial fibrosis on renal biopsy (r=0.727 ; p=0.0001). Conclusion: According to our results, parenchymal stiffness obtained by TE reflects interstitial fibrosis. Therefore, TE provides the opportunity for non-invasive screening of CAN.
Rad je indeksiran u
bazama podataka:
MEDLINE
Scopus
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
Upisao u CROSBI: Sanjin Rački (sanjin.racki@uniri.hr), 28. Lip. 2014. u 18:21 sati



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