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Pregled bibliografske jedinice broj: 702874

Zbornik radova

Autori: Zoričić Cvek, Sanja; Đudarić, Luka; Cvijanović, Olga; Marić, Ivana; Šestan, Branko; Šantić, Veljko; Pilipović, Kristina
Naslov: rhBMP-7 treated IRBR implants on rat calvarial defects
Izvornik: 6th International Symposium of Clinical and Applied Anatomy - Book of Abstracts / Zoričić Cvek, Sanja (ur.). - Rijeka :
Skup: 6th International Symposium of Clinical and Applied Anatomy
Mjesto i datum: Rijeka ; Krk, Hrvatska, 26-29.6.2014.
Ključne riječi: rhBMP-7; IRBR implants; bone
Sažetak:
Aim: The cellular and molecular sequences of the osteogenesis induced by rhBMP-7 bound to inactive rat bone residue (IRBR) as a carrier implanted in rats have been studied at calvarial defect. Methods and experimental design: To create a parcial defect of calvarial rat bone, periosteum and bone of the frontoparietooccipital complex were grinded with dental burr and special care was taken to avoid cranial wall opening. The implants were harvested at day 7th, 12th and 21th. Tissue samples were analysed by histology, histochemistry and histomorphometry. Results: The results of this study showed different initial tissue response in relation to control samples of implants (contain no active osteoinductive BMP-7). On rat calvarial deffect BMP-7 induced direct bone formation (intramembranous bone formation) and fuses with the underlying bone deffect. In the underlying bone remodeling is active as early as day 12th and is completely fused with the impalnt by day 21st.The results of histomorphometry showed more prounanced and rapid osteogenesis in relation to control animals. Conclusion: The results of this study suggest that rhBMP-7 induced early bone formation and promote osteogenesis to deffect healing. The bone forming process is manly direct ie. intramembranous bone formation.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 062-0000000-3559
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Upisao u CROSBI: Luka Đudarić (luka.dudaric@uniri.hr), 30. Lip. 2014. u 12:22 sati



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