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Pregled bibliografske jedinice broj: 713151

Zbornik radova

Autori: Zoričić Cvek, Sanja; Đudarić, Luka; , Cvijanović, Olga; Marić, Ivana; Šestan, Branko; Šantić, Veljko; Pilipović, Kristina
Naslov: BMPs and their antagonists in development and growth of human knee joint osteophytes
Izvornik: 6th International Symposium of Clinical and Applied Anatomy : abstracts ; u: Revista Argentina de Anatomía Clínica 6 (2014) (2) / Biasutto, Susana (ur.). - General Paz, Córdoba : Asociación Argentina de Anatomía Clínica , 2014. 134-135.
ISSN: 1850-8023
Skup: International Symposium of Clinical and Applied Anatomy (6 ; 2014)
Mjesto i datum: Rijeka - Krk, Hrvatska, 26-29.06.2014.
Ključne riječi: BMP; BMP antagonists; osteophyte
Sažetak:
The osteophytes are bone spurs overgrowing the edge of the articular cartilage during the course of osteoarthritis (OA). Although the cellular mechanism of their development and growth is revealed and resemblin normal bone development, there is still debate concerning molecular mechanism of their growth. Since the role of bone morphogenetic proteins family members (BMPs) in bone development is well established and documented, the members of the BMPs as an important member of the local grpwth factor network and their extracellular inhibitors were recognized as an important factors that could modulate, even cease development and growth of osteophytes. The aim of our study was to analyse expression and localization of the most potent osteoinductive BMP-2, -4 and -7, and their extracellular inhibitors gremlin, chordin, follisatin and noggin. The study was performed on tissue collection of 25 osteophytes collected during total knee joint replacement surgery due to severe OA, and on 10 samples of normal knee joint tissues from individuals undergoing autopsy. The expression of molecular factors was analysed using immunohistochemistry and Western blot analysis. Our result demonstrate the significant differences in BMPs and their antagonists expression between normal and OA affected joint tissue and suggest the potent role of these molecular factors in pathogenesis and / or mechanism of growth and development of human knee joint osteophytes.
Vrsta sudjelovanja: Predavanje
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 062-0000000-3559
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.anatclinar.com.ar
http://www.anatclinar.com.ar/images/stories/vol6_num2_jul14/Resumenes.pdf
Upisao u CROSBI: Luka Đudarić (luka.dudaric@uniri.hr), 5. Ruj. 2014. u 20:54 sati
Napomene:
Sažetak ovog kongresnog priopćenja objavljen je u Knjizi sažetaka ; Zoričić Cvek, Sanja (ur.) ; Rijeka, 2014 ; str. 14-14.



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