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Autori: Rajič, Jelena; Pilipović, Kristina; Križ, Jasna; Župan, Gordana
Naslov: Learning and motor performances after repetitive traumatic brain injury in the mouse.
Izvornik: Sinapsa Neuroscience Conference'15 / Andraž Matkovič, Blaž Koritnik (ur.). - Ljubljana : SiNAPSA, Slovenian Neuroscience Association , 2015. 70-70.
Skup: Sinapsa Neuroscience Conference'15
Mjesto i datum: Ljubljana, Slovenija, 15-17.05.2015.
Ključne riječi: repetitive traumatic brain injury; rotarod; passive avoidance; mouse
Sažetak:
People often sustain repetitive traumatic brain injury (rTBI), mostly in contact sports and as a result of domestic violence and military combats. It is suggested that rTBI is associated with persistent alterations in cognition, emotional functioning, behavior and motor performance. The aim of our research was to investigate cumulative effects of rTBI on learning and motor abilities in adult male C57BL/6 mice previously trained in the passive avoidance and rotarod tasks. The animals were subjected to a repetitive brain injury using a noninvasive modified weight drop model by Marmarou. Apparatus consisted of a vertical tube, box below the tube with a piece of aluminum foil on its upper side, on which the animals were situated immediately after isoflurane anesthesia, and a steel weight suspended on a nylon thread. Weight was set above the mouse head, pulled upward to a height of 1 m and dropped. rTBIs were performed twice daily, 6 hours apart, during 5 consecutive days. Sham treated, control animals were anesthetized but not subjected to the head impact. One day after the final injury or sham procedure, the mice were retested on passive avoidance task. Additionally, they were tested on the rotarod apparatus either one or three days after the last traumatic or sham injury. Mentioned preliminary results indicate no significant differences in learning or motor performances in traumatized animals compared to the mice of the control group in our experimental conditions.
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Projekt / tema: 13.06.1.1.09
Izvorni jezik: ENG
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
Upisao u CROSBI: Jelena Rajič (jelena.rajic@uniri.hr), 19. Svi. 2015. u 09:57 sati



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