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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 813334

Časopis

Autori: Valković, Toni; Babarović, Emina; Lučin, Ksenija; Štifter, Sanja; Aralica, Merica; Seili-Bekafigo, Irena; Duletić-Načinović, Antica; Jonjić, Nives
Naslov: Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma
( Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma )
Izvornik: BioMed Research International (2314-6141) (2016); 7870590-1-7870590-7
Vrsta rada: članak
Ključne riječi: MCP-1; angiogenesis; multiple myeloma
( MCP-1; angiogenesis; multiple myeloma )
Sažetak:
The aim of this pilot study was to determine the plasma levels of monocyte chemotactic protein-1 (MCP-1) and possible associations with angiogenesis and the main clinical features of untreated patients with multiple myeloma (MM). ELISA was used to determine plasma MCP-1 levels in 45 newly diagnosed MM patients and 24 healthy controls. The blood vessels were highlighted by immunohistochemical staining, and computer- assisted image analysis was used for more objective and accurate determination of two parameters of angiogenesis: microvessel density (MVD) and total vascular area (TVA). The plasma levels of MCP-1 were compared to these parameters and the presence of anemia, renal dysfunction, and bone lesions. A significant positive correlation was found between plasma MCP-1 concentrations and TVA (p = 0.02). The MCP-1 levels were significantly higher in MM patients with evident bone lesions (p = 0.01), renal dysfunction (p = 0.02), or anemia (p = 0.04). Therefore, our preliminary results found a positive association between plasma MCP-1 levels, angiogenesis (expressed as TVA), and clinical features in patients with MM. However, additional prospective studies with a respectable number of patients should be performed to authenticate these results and establish MCP-1 as a possible target of active treatment.
Projekt / tema: 062-1081872-0091, 062-0620095-0078, 062-0620095-0079, 062-0620095-0082
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
Puni text rada: 813334.7870590-1.pdf (tekst priložen 2. Svi. 2016. u 13:07 sati)
URL Internet adrese: http://www.hindawi.com/journals/bmri/2016/7870590/
http://dx.doi.org/10.1155/2016/7870590
Broj citata:
Altmetric:
DOI: 10.1155/2016/7870590
URL cjelovitog teksta:
Časopis izlazi u samo elektroničkom izdanju: DA
Google Scholar: Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma
Upisao u CROSBI: Ksenija Lučin (Ksenija.Lucin@medri.hr), 2. Svi. 2016. u 13:07 sati



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