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 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 813362

Časopis

Autori: Ahel, Juraj; Dordevic, Gordana; Markic, Dean; Mozetic Vladimir; Spanjol, Josip; Grahovac, Blazenka; Stifter, Sanja
Naslov: Nuclear EGFR Characterize Still Controlled Proliferation Retained in Better Differentiated Clear Cell RCC
( Nuclear EGFR Characterize Still Controlled Proliferation Retained in Better Differentiated Clear Cell RCC )
Izvornik: Medical Hypotheses (0306-9877) 85 (2015), 2; 183-185
Vrsta rada: članak
Ključne riječi: Renal cell carcinoma (RCC) ; EGFR expression ; tumor differentiation
( Renal cell carcinoma (RCC) ; EGFR expression ; tumor differentiation )
Sažetak:
Renal cell carcinoma (RCC) is the most common solid kidney tumor representing 2-3% of all cancers, with the highest frequency occurring in Western countries. There was a worldwide and European annual increase in incidence of approximately 2% although incidence has been stabilized in last few years. One third of the patients already have metastases in the time of the diagnosis with poor prognosis because RCC are radio and chemoresistant. The prognostic value of EGFR over-expression in RCC is a controversial issue that could be explained by different histological types of study tumors and non-standardized criteria for evaluation of expression. Recent evidences points to a new mode of EGFR signaling pathway in which activated EGFR undergoes nuclear translocalization and then, as transcription factor, mediates gene expression and other cellular events required for highly proliferating activities. According to our observations, the membranous expression of EGFR associates with high nuclear grade and poor differentiated tumors. On the other hand, nuclear EGFR expression was high in low nuclear graded and well differentiated tumors with good prognosis. We hypothesize that this mode of EGFR signaling characterizes still controlled proliferation retained in well differentiated RCC with Furhman nuclear grade I or II.
Izvorni jezik: eng
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Ostalo
Znanstvena područja:
Temeljne medicinske znanosti,Kliničke medicinske znanosti
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S0306987715001887
Broj citata:
Altmetric:
DOI: 10.1016/j.mehy.2015.04.033.
URL cjelovitog teksta:
Google Scholar: Nuclear EGFR Characterize Still Controlled Proliferation Retained in Better Differentiated Clear Cell RCC
Upisao u CROSBI: Gordana Đorđević (gordana.dordevic@uniri.hr), 2. Svi. 2016. u 14:35 sati



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