crta
Hrvatska znanstvena Sekcija img
bibliografija
3 gif
 Naslovna
 O projektu
 FAQ
 Kontakt
4 gif
Pregledavanje radova
Jednostavno pretraživanje
Napredno pretraživanje
Skupni podaci
Upis novih radova
Upute
Ispravci prijavljenih radova
Ostale bibliografije
Slični projekti
 Bibliografske baze podataka

Pregled bibliografske jedinice broj: 821170

Časopis

Autori: Marinić, Jelena; Broznić, Dalibor; Milin, Čedomila
Naslov: Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes
Izvornik: Oxidative Medicine and Cellular Longevity (1942-0900) 2016 (2016); 1-14
Vrsta rada: članak
Ključne riječi: γ-Glutamylcysteine synthetase ; Heme oxygenase-1 ; Hepatic oxidative state ; Liver regeneration ; Nrf2 ; Olive oil polyphenols ; Partial hepatectomy
Sažetak:
Polyphenols can act as oxidants in some conditions, inducing redox-sensitive genes. We investigated the effect of preexposure to the olive oil polyphenols extract (PFE) on time- dependent changes in the hepatic oxidative state in a model of liver regeneration—a process in which oxidative stress associated with the metabolic overload accounts for the early events that contribute to the onset of liver self-repair. Liver regeneration was induced by one-third hepatectomy in mice. Prior to hepatectomy, mice were intraperitoneally given either PFE (50 mg/kg body weight) or saline for seven consecutive days, while respective controls received vehicle alone. Redox state-regulating enzymes and thiol proteins along with the mRNA levels of Nrf2 gene and its targets -glutamylcysteine synthetase and heme oxygenase-1 were determined at different time intervals after hepatectomy. The liver mass restoration was calculated to assess hepatic regeneration. The resulting data demonstrate the effectiveness of preexposure to PFE in stimulating liver regeneration in a model of a small tissue loss which may be ascribed to the transient increase in oxidant load during the first hours after hepatectomy and associated induction of stress response gene-profiles under the control of Nrf2.
Projekt / tema: 062-0621341-0061
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Kemija,Biologija,Temeljne medicinske znanosti
URL Internet adrese: http://www.hindawi.com/journals/omcl/2016/9191407/
Broj citata:
Altmetric:
DOI: 10.1155/2016/9191407
URL cjelovitog teksta: http://www.hindawi.com/journals/omcl/2016/9191407/
Google Scholar: Preexposure to Olive Oil Polyphenols Extract Increases Oxidative Load and Improves Liver Mass Restoration after Hepatectomy in Mice via Stress-Sensitive Genes
Upisao u CROSBI: Jelena Marinić (jelena.marinic@uniri.hr), 13. Lip. 2016. u 14:49 sati



  Verzija za printanje   za tiskati


upomoc
foot_4