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Pregled bibliografske jedinice broj: 822455

Časopis

Autori: Ćurko-Cofek, Božena; Grubić Kezele, Tanja; Marinić, Jelena; Tota, Marin; Starčević Čizmarević, Nada; Milin, Čedomila; Ristić, Smiljana; Radošević-Stašić, Biserka; Barac- Latas, Vesna
Naslov: Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis
Izvornik: Neurotoxicology (0161-813X) 57 (2016); 1-12
Vrsta rada: članak
Ključne riječi: Chronic relapsing experimental autoimmune encephalomyelitis ; gender ; iron overload ; lipid peroxidation ; brain ; spinal cord ; liver.
Sažetak:
To analyze iron- and gender-dependent mechanisms possibly involved in pathogenesis of multiple sclerosis (MS) in this study we evaluated the effects of iron overload (IO) on iron status and lipid peroxidation processes (LPO) in tissues of female and male DA rats during chronic relapsing experimental autoimmune encephalomyelitis, a well- established MS animal model. Rats were treated by iron sucrose (75 mg/kg bw/day) or with saline solution during two weeks before the sensitization with bovine brain homogenate in complete Freund's adjuvant. Clinical signs of EAE were monitored during 29 days. Serum and tissues of CNS and liver were sampled before immunization and at day 13th post immunization (during acute phase of EAE). The determination of ferritin, iron, malondialdehyde (MDA) and 4- hydroxynonenal (4-HNE) and evaluation of histopathology were performed by ELISA, ICP spectrometry and immunohistochemistry. Results showed that IO in female EAE rats accelerated the onset of disease. In contrast, in male rats it accelerated the progression of disease and increased the mortality rate. During acute phase of EAE female IO rats sequestered more Fe in the liver, spinal cord and in the brain and produced more ferritin than male EAE rats. Male rats, however, reacted on IO by higher production of MDA or 4-HNE in the neural tissues and showed greater signs of plaque formation and gliosis in spinal cord. The data point to sexual dimorphism in mechanisms that regulate peripheral and brain iron homeostasis and imply that men and women during MS might be differentially vulnerable to exogenous iron overload.
Projekt / tema: 13.06.2.2.61, 13.06.1.1.13, 13.06.1.1.16
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S0161813X16301632
Broj citata:
Altmetric:
DOI: 10.1016/j.neuro.2016.08.014
URL cjelovitog teksta:
Google Scholar: Chronic iron overload induces gender-dependent changes in iron homeostasis, lipid peroxidation and clinical course of experimental autoimmune encephalomyelitis
Upisao u CROSBI: Biserka Radošević-Stašić (biserkars@uniri.hr), 20. Lip. 2016. u 10:53 sati



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