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Pregled bibliografske jedinice broj: 875543

Časopis

Autori: Kero, Darko; Cigić, Livia; Medvedec Mikić, Ivana; Galić, Tea; Cubela, Mladen; Vukojević, Katarina; Saraga-Babić, Mirna
Naslov: Involvement of IGF-2, IGF-1R, IGF-2R and PTEN in development of human tooth germ - an immunohistochemical study
Izvornik: Organogenesis (1547-6278) 12 (2016), 3; 152-167
Vrsta rada: članak
Ključne riječi: differentiation, human tooth development, IGF-axis, IGF-2, IGF-1R, IGF-2R, proliferation, PTEN
Sažetak:
Insulin-Like Growth Factor 2 (IGF-2) is a peptide hormone essential for prenatal growth and development. IGF-2 exerts its mitogenic effects via Insulin-Like Growth Factor 1 Receptor (IGF-1R), and is eliminated by binding to Insulin-Like Growth Receptor 2 (IGF-2R). IGF-2 is also negatively regulated by Phosphatase and Tensin Homolog (PTEN), a phosphatase mutated in various tumors. Not much is known about the interplay between these factors during human odontogenesis. In this study, expression patterns of IGF-2, IGF-1R, IGF-2R and PTEN were analyzed by double immunofluorescence in incisor human tooth germs during the foetal period of development between the 7th and 20th gestational week. Throughout the investigated period, IGF-2 was mostly expressed in enamel organ, whereas mild to moderate expression of PTEN could be seen in dental papilla and parts of enamel organ. Expression of IGF-1R was ubiquitous and displayed strong intensity throughout the entire enamel organ. In contrast, expression of IGF-2R had rather erratic pattern in enamel organ and dental papilla alike. Expression patterns of IGF-2, IGF-1R, IGF-2R and PTEN in highly proliferative cervical loops, as well as in differentiating pre-ameloblasts and pre- odontoblasts of cusp tip region during the early and late bell stages when enamel organ acquires definitive shape, indicate importance of these factors in crown morphogenesis of human incisor. Taken together, our data suggest the involvement of IGF-2, IGF-1R, IGF-2R and PTEN in temporo-spatial patterning of basic cellular processes (proliferation, differentiation) during normal tooth development. They are also relevant for improving knowledge of molecular basis of human odontogenesis.
Izvorni jezik: ENG
Rad je citiran u
bazama podataka:
Web of Science: Science Citation
Current Contents Citation Index
Web of Science: Science Citation Index Expanded
MEDLINE
Scopus
Kategorija: Znanstveni
Znanstvena područja:
Temeljne medicinske znanosti,Dentalna medicina
URL Internet adrese: http://dx.doi.org/10.1080/15476278.2016.1197460
http://www.tandfonline.com/doi/full/10.1080/15476278.2016.1197460
Broj citata:
Altmetric:
DOI: 10.1080/15476278.2016.1197460
URL cjelovitog teksta:
Google Scholar: Involvement of IGF-2, IGF-1R, IGF-2R and PTEN in development of human tooth germ - an immunohistochemical study
Upisao u CROSBI: Ivana Medvedec Mikić (ivana.medvedec@mefst.hr), 18. Svi. 2017. u 09:38 sati



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