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Autori: Poropat, Goran; Giljača, Vanja; Licul, Vanja; Hauser, Goran; Milić, Sandra; Štimac, Davor
Naslov: Imipenem prophylaxis for predicted severe acute pancreatitis - Preliminary results of a randomized clinical trial
( Imipenem prophylaxis for predicted severe acute pancreatitis - Preliminary results of a randomized clinical trial )
Izvornik: Pancreatology
ISSN: 1424-3903
Skup: 48th European Pancreatic Club
Mjesto i datum: Liverpool, Velika Britanija, 6-9.7.2016.
Ključne riječi: Acute pancreatitis, imipenem, prophylaxis, randomized controlled trial
( Acute pancreatitis, imipenem, prophylaxis, randomized controlled trial )
Sažetak:
Introduction: Infected necrosis is a serious complication of acute pancreatitis leading to a mortality rate of about 40%. Although prophylactic antibiotics are not recommended, meta-analytic data show that imipenem significantly reduces the rate of infected necrosis. Aims: To evaluate the prophylactic use of imipenem in patients with predicted severe acute pancreatitis. Patients & methods: We conducted a single- center, prospective randomized trial. Patients with AP and an APACHE II  8 were randomized to receive either imipenem 500 mg i.v. three times daily for the first ten days or an identical placebo. Exclusion criteria included age < 18 years, any infection present at admission, chronic pancreatitis, active malignancy, immunodeficiency, post-surgical patients, pregnant and breastfeeding women and patients unwilling to participate. Concomitant treatment was similar in both groups. All patients had an abdominal CT scan performed between days 3 to 7, and in cases of clinically suspected infected pancreatic necrosis. Results: Forty- seven consecutive patients were randomized. Twentythree received imipenem and 24 received placebo. Three patients died in the imipenem group, while two patients died in the placebo group (p=0, 667). There were no differences in the occurrence of infected necrosis, with 2 vs. 3 cases, respectively. Other local complications were present in 7 and 13 patients (p¼0, 142), while persistent organ failure was present in 4 and 5 patients (p¼1, 00) in imipenem and placebo group, respectively. Other infection were detected in 2 patients receiving imipenem and 5 patients on placebo (p¼0, 416). Conclusion: Preliminary data showed no significant beneficial effects of prophylactic imipenem in patients with predicted severe acute pancreatitis.
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Vrsta sudjelovanja: Poster
Vrsta prezentacije u zborniku: Sažetak
Vrsta recenzije: Međunarodna recenzija
Izvorni jezik: eng
Kategorija: Znanstveni
Znanstvena područja:
Kliničke medicinske znanosti
Upisao u CROSBI: Goran Poropat (goran.poropat@uniri.hr), 8. Lip. 2017. u 17:03 sati



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