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Pregled bibliografske jedinice broj: 887686

Časopis

Autori: Boban, Marko; Žulj, Marinko; Peršić, Viktor; Medved, Igor; Zekanović, Drazen; Včev, Aleksandar
Naslov: Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia
( Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia )
Izvornik: International journal of cardiology (0167-5273) 119 (2016); 277-281
Vrsta rada: članak
Ključne riječi: Proton pump inhibitor (PPI) ; Ischemic heart disease ; Valvular heart disease ; Anemia ; Weight loss
( Proton pump inhibitor (PPI) ; Ischemic heart disease ; Valvular heart disease ; Anemia ; Weight loss )
Sažetak:
Proton pump inhibitors (PPIs) are among the commonest drugs used nowadays. The aim of our study was to analyze prolonged utilization of proton pump inhibitors in medical therapy of patients with ischemic and valvular heart disease. Secondly, profile of utilization was scrutinized to patient characteristics and type of cardiovascular treatments. The study included consecutive patients scheduled for cardiovascular rehabilitation 2–6 months after index cardiovascular treatment. Two hundred ninety-four patients (n = 294/604 ; 48.7%) have been using proton pump inhibitor in their therapy after index cardiovascular treatment. Cardiovascular treatments were powerfully connected with utilization of PPIs ; surgery 5.77 (95%-confidence intervals [CI]: 4.05–8.22 ; p < 0.001) and PCI 0.15 (CI: 0.10– 0.22 ; p < 0.001). The odds for having proton pump inhibitor in their chronic therapy were increased for atrial fibrillation 1.87 (CI: 1.08–3.23 ; p = 0.025) and decreased for obesity 0.65 (CI: 0.45–0.96 ; p = 0.035) ; surviving myocardial infarction 0.49 (CI: 0.29–0.83 ; p = 0.035). Multinomial logistic regression controlled for existence of chronic renal disease found no significant association of renal dysfunction and PPI therapy. The existence of anemia was significantly increased in patients taking PPIs than controls ; 6.00 (CI: 3.85–9.33 ; p < 0.001). The use of PPI was also associated with worsening of metabolic profile, in part due to decreased utilization of ACE-inhibitors and statins. PPI consumption correlated with age of patients (Rho = 0.216 ; p < 0.001). High proportion of cardiovascular, particularly surgical patients with ischemic and valvular heart disease utilized proton pump inhibitor in prolonged courses. Prolonged courses of PPIs were connected with existence and worsening of red blood count indexes, older age, lesser weight of patients and underutilization of cardioprotective drugs.
Izvorni jezik: eng
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bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
SCI-EXP, SSCI i/ili A&HCI
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
URL Internet adrese: http://www.sciencedirect.com/science/article/pii/S0167527316310658
https://doi.org/10.1016/j.ijcard.2016.06.058
Broj citata:
Altmetric:
DOI: 10.1016/j.ijcard.2016.06.058
URL cjelovitog teksta:
Google Scholar: Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia
Upisao u CROSBI: Jelena Jakab (jelena.jakab@mefos.hr), 25. Srp. 2017. u 17:03 sati



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