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Pregled bibliografske jedinice broj: 950080

Časopis

Autori: Cokarić Brdovčak, Maja; Zubković, Andreja; Ferenčić, Antun; Šoša, Ivan; Stemberga, Valter; Cuculić, Dražen; Rokić, Filip; Vugrek, Oliver; Hackenberg, Michael; Jurak, Igor
Naslov: Herpes simplex virus 1 miRNA sequence variations in latently infected human trigeminal ganglia
Izvornik: Virus Research (0168-1702) 256 (2018); 90-95
Vrsta rada: članak
Ključne riječi: HSV-1, miRNA
Sažetak:
Human herpes simplex virus 1 (HSV-1) expresses numerous miRNAs, the function of which is not well understood. Several qualitative and quantitative analyses of HSV-1 miRNAs have been performed on infected cells in culture and animal models, however, there is very limited knowledge of their expression in human samples. We sequenced small-RNA libraries of RNA derived from human trigeminal ganglia latently infected with HSV-1 and Varicella zoster virus (VZV) and detected only a small subset of HSV-1 miRNA. The most abundantly expressed miRNAs are miR-H2, miRNA that regulates the expression of immediate early gene ICP0, and miR-H3 and -H4, both miRNAs expressed antisense to the transcript encoding the major neurovirulence factor ICP34.5. The sequence of many HSV-1 miRNAs detected in human samples was different from the sequences deposited in miRBase, which might significantly affect targeted functional analyses.
Izvorni jezik: ENG
Rad je indeksiran u
bazama podataka:
Current Contents Connect (CCC)
MEDLINE
Scopus
Science Citation Index Expanded (SCI-EXP) (sastavni dio Web of Science Core Collectiona)
Kategorija: Znanstveni
Broj citata:
Altmetric:
DOI: 10.1016/j.virusres.2018.08.002
URL cjelovitog teksta:
Google Scholar: Herpes simplex virus 1 miRNA sequence variations in latently infected human trigeminal ganglia
Upisao u CROSBI: Igor Jurak (igor.jurak@biotech.uniri.hr), 7. Kol. 2018. u 07:59 sati



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